Show simple item record Elwood, Peter C. Gallagher, Alison M. Duthie, Garry G. Mur, Luis A. J. Morgan, Gareth 2010-03-23T16:26:52Z 2010-03-23T16:26:52Z 2009-04-11
dc.identifier.citation Elwood , P C , Gallagher , A M , Duthie , G G , Mur , L A J & Morgan , G 2009 , ' Aspirin, salicylates and cancer ' The Lancet , vol 373 , no. 9671 , pp. 1301-1309 . DOI: 10.1016/S0140-6736(09)60243-9 en
dc.identifier.issn 1474-547X
dc.identifier.other PURE: 146634
dc.identifier.other PURE UUID: 8d423358-327a-46ad-8f41-fb46f3efc8a2
dc.identifier.other dspace: 2160/4515
dc.identifier.other Ibers_20121112_1204.csv: row: 526
dc.identifier.other Scopus: 64049106907
dc.description Elwood, P. C., Gallagher, A. M., Duthie, G. G., Mur, L. A. J., Morgan, G. (2009). Aspirin, salicylates and cancer. The Lancet, 373, (9671), 1301-1309. IMPF: 30.76 RONO: 00 en
dc.description.abstract Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered. en
dc.format.extent 9 en
dc.language.iso eng
dc.relation.ispartof The Lancet en
dc.rights en
dc.title Aspirin, salicylates and cancer en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en

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