Aspirin, salicylates and cancer

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dc.contributor.author Elwood, Peter C.
dc.contributor.author Gallagher, Alison M.
dc.contributor.author Duthie, Garry G.
dc.contributor.author Mur, Luis A. J.
dc.contributor.author Morgan, Gareth
dc.date.accessioned 2010-03-23T16:26:52Z
dc.date.available 2010-03-23T16:26:52Z
dc.date.issued 2009-04-11
dc.identifier.citation Elwood , P C , Gallagher , A M , Duthie , G G , Mur , L A J & Morgan , G 2009 , ' Aspirin, salicylates and cancer ' The Lancet , vol 373 , no. 9671 , pp. 1301-1309 . , 10.1016/S0140-6736(09)60243-9 en
dc.identifier.other PURE: 146634
dc.identifier.other dspace: 2160/4515
dc.identifier.uri http://hdl.handle.net/2160/4515
dc.description Elwood, P. C., Gallagher, A. M., Duthie, G. G., Mur, L. A. J., Morgan, G. (2009). Aspirin, salicylates and cancer. The Lancet, 373, (9671), 1301-1309. IMPF: 30.76 RONO: 00 en
dc.description.abstract Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered. en
dc.format.extent 9 en
dc.language.iso eng
dc.relation.ispartof The Lancet en
dc.title Aspirin, salicylates and cancer en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1016/S0140-6736(09)60243-9
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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