Browsing Gwyddorau Biolegol, Amgylcheddol a Gwledig / Biological, Environmental & Rural Sciences by Author "Adachi, Isao"

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Browsing Gwyddorau Biolegol, Amgylcheddol a Gwledig / Biological, Environmental & Rural Sciences by Author "Adachi, Isao"

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  • Kato, Atsushi; Kobayashi, Kaori; Narukawa, Kayo; Minoshima, Yuka; Adachi, Isao; Hirono, Shuichi; Nash, Robert J. (2010-10-01)
    We report the structure–activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity ...
  • Kato, Atsushi; Kano, E.; Adachi, Isao; Molyneux, R. J.; Watson, Alison A.; Nash, Robert J.; Fleet, George W. J.; Wormald, M. R.; Kizu, Haruhisa; Ikeda, Kyoko; Asano, Naoki (2003-02-07)
    The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legume Castanospermum australe is also ...
  • Kato, Atsushi; Kato, Noriko; Miyauchi, Saori; Minoshima, Yuka; Adachi, Isao; Ikeda, Kyoko; Asano, Naoki; Watson, Alison A.; Nash, Robert J. (2008-03)
    Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine ...
  • Kato, Atsushi; Yasuko, H.; Goto, H.; Hollinshead, Jackie; Nash, Robert J.; Adachi, Isao (2009-03-01)
    Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active ...
  • Kato, Atsushi; Nash, Robert J.; Asano, Naoki; Okamoto, T.; Kizu, Haruhisa; Higuchi, Y.; Adachi, Isao; Goto, H.; Hollinshead, Jackie (2006-08-05)
    Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, ...
  • Minoshima, Y.; Kato, Atsushi; Watson, Alison A.; Yamamoto, J.; Adachi, Isao; Nash, Robert J. (2008-08-06)
    Matricaria chamomilla L., known as “chamomile”, has been used as an herbal tea or supplementary food all over the world. We investigated the effects of chamomile hot water extract and its major components on the prevention ...
  • Nash, Robert J.; Minami, Y.; Nasu, N.; Asano, Naoki; Kato, Atsushi; Watson, Alison A.; Takebayashi, K.; Adachi, Isao; Sanae, F. (2008)
    Flavonoids are ubiquitous components in vegetables, fruits, tea, and wine. Therefore, they are often consumed in large quantities in our daily diet. Several flavonoids have been shown to have potential as antidiabetic ...

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