Browsing Gwyddorau Biolegol, Amgylcheddol a Gwledig / Biological, Environmental & Rural Sciences by Author "Kato, Atsushi"

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  • Kato, Atsushi; Kobayashi, Kaori; Narukawa, Kayo; Minoshima, Yuka; Adachi, Isao; Hirono, Shuichi; Nash, Robert J. (2010-10-01)
    We report the structure–activity relationship of a series of coumarins as aldose reductase 2 (ALR2) inhibitors and their suppressive effect on the accumulation of galactitol in the rat lens. We evaluated their ALR2 selectivity ...
  • Haraguchi, Mitsue; Gorniak, Silvana L.; Ikeda, Kyoko; Minami, Yasuhiro; Kato, Atsushi; Watson, Alison A.; Nash, Robert J.; Molyneux, Russell J.; Asano, Naoki (2003-07-11)
    Natural intoxication of livestock by the ingestion of Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions of the world. Polyhydroxylated alkaloids were isolated from the leaves, flowers, and seeds of the ...
  • Kato, Atsushi; Kano, Erika; Adachi, Isao; Molyneux, Russell J.; Watson, Alison A.; Nash, Robert J.; Fleet, George W. J.; Wormald, Mark R.; Kizu, Haruhisa; Ikeda, Kyoko; Asano, Naoki (2003-02-07)
    The first polyhydroxylated pyrrolizidine alkaloid with a hydroxymethyl group at C-3 was isolated from pods of Alexa leiopetala (Leguminosae) and designated alexine 1. The Australian legume Castanospermum australe is also ...
  • Asano, Naoki; Yokoyama, Kae; Sakurai, Mio; Ikeda, Kyoko; Kizu, Haruhisa; Kato, Atsushi; Arisawa, Munehisa; Hoke, Dirk; Watson, Alison A.; Nash, Robert J. (2001-07)
    Three dihydroxynortropanes, 2α,7β-dihydroxynortropane, 2α,3β-dihydroxynortropane, and 3α,7β-dihydroxynortropane, were isolated from calystegine-producing plants in the families Convolvulaceae and Solanaceae. 2α,7β-Dihydr ...
  • Kato, Atsushi; Kato, Noriko; Miyauchi, Saori; Minoshima, Yuka; Adachi, Isao; Ikeda, Kyoko; Asano, Naoki; Watson, Alison A.; Nash, Robert J. (2008-03)
    Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine ...
  • Kato, Atsushi; Yasuko, H.; Goto, H.; Hollinshead, Jackie; Nash, Robert J.; Adachi, Isao (2009-03-01)
    Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active ...
  • Kato, Atsushi; Nash, Robert J.; Asano, Naoki; Okamoto, T.; Kizu, Haruhisa; Higuchi, Y.; Adachi, Isao; Goto, H.; Hollinshead, Jackie (2006-08-05)
    Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world. Scientific research has gradually verified the antidiabetic effects of ginger. Especially gingerols, ...
  • Jones, Laurence; Hollinshead, Jackie; Fleet, George W. J.; Thompson, Amber L.; Watkin, David J.; Gal, Zoltan A.; Jenkinson, Sarah F.; Kato, Atsushi; Nash, Robert J. (2010-09)
    The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report ...
  • Mercer, Thomas B.; Jenkinson, Sarah F.; Bartholomew, Barbara; Nash, Robert J.; Miyauchi, Saori; Kato, Atsushi; Fleet, George W. J. (2009-10-20)
    Benzhydryl protection by diphenyldiazomethane of an alcohol in enantiomeric base-sensitive ribonolactones allows short efficient syntheses of 1,4-dideoxy-1,4-imino-D-lyxitol (DIL) and of 1,4-dideoxy-1,4-imino-L-lyxitol ...
  • Yasuda, Kayo; Kizu, Haruhisa; Yamashita, Toru; Kameda, Yukihiko; Kato, Atsushi; Nash, Robert J.; Fleet, George W. J.; Molyneux, Russell J.; Asano, Naoki (2002-02-06)
    Chromatographic separation of the pod extract of Angylocalyx pynaertii resulted in the isolation of 13 sugar-mimic alkaloids (1−13). The structures of the new alkaloids were elucidated by spectroscopic methods as the ...
  • Asano, Naoki; Yasuda, Kayo; Kizu, Haruhisa; Kato, Atsushi; Fan, Jian-Qiang; Nash, Robert J.; Fleet, George W. J.; Molyneux, Russell J. (2001-01)
    The extract of bark of Angylocalyx pynaertii (Leguminosae) was found to potently inhibit mammalian α- l-fucosidases. A thorough examination of the extract resulted in the discovery of 15 polyhydroxylated alkaloids, including ...
  • Asano, Naoki; Yamashita, Toru; Yasuda, Kayo; Ikeda, Kyoko; Kizu, Haruhisa; Kameda, Yukihiko; Kato, Atsushi; Nash, Robert J.; Lee, Heui S.; Ryu, Kang S. (2001-08-16)
    New polyhydroxylated alkaloids, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidine-N-propionamide from the root bark of Morus alba L., and 4-O-α-d-galactopyranosyl-calystegine B2 and 3β,6β-dihydroxynortropane from the ...
  • Kato, Atsushi; Minoshima, Yuka; Yamamoto, Jo; Adachi, Isao; Watson, Alison A.; Nash, Robert J. (2008-08-06)
    Matricaria chamomilla L., known as “chamomile”, has been used as an herbal tea or supplementary food all over the world. We investigated the effects of chamomile hot water extract and its major components on the prevention ...
  • Michalik, Agnieszka; Hollinshead, Jackie; Jones, Laurence Edmund; Fleet, George W. J.; Yu, Chu-Yi; Hu, Xiang-Guo; van Well, Renate; Horne, Graeme; Wilson, Francis X.; Kato, Atsushi; Jenkinson, Sarah F.; Nash, Robert J. (2010-09-20)
    The novel iminosugar (1R,2S,3R,5R,8aR)-3-(hydroxymethyl)-5-methyloctahydroindolizine-1,2-diol (steviamine) was isolated from leaf material of Stevia rebaudiana and leaves and bulbs of Veltheimia capensis. This is the first ...
  • Nash, Robert J.; Minami, Y.; Nasu, N.; Asano, Naoki; Kato, Atsushi; Watson, Alison A.; Takebayashi, K.; Adachi, Isao; Sanae, F. (2008)
    Flavonoids are ubiquitous components in vegetables, fruits, tea, and wine. Therefore, they are often consumed in large quantities in our daily diet. Several flavonoids have been shown to have potential as antidiabetic ...
  • Zhang, Wei; Sato, Kasumi; Kato, Atsushi; Jia, Yue-mei; Hu, Xiang-guo; Wilson, Francis X.; Van Well, Renate; Horne, Graeme; Fleet, George W. J.; Nash, Robert J.; Yu, Chu-yi (2011-08-19)
    Total synthesis of the proposed structure of (-)-hyacinthacine C(5) and its epimers at C6 and C7 is described. A key step of the synthesis was the construction of the bicyclic pyrrolizidine system by means of a nucleophilic ...

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