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Browsing Gwyddorau Biolegol, Amgylcheddol a Gwledig / Biological, Environmental & Rural Sciences by Author

Browsing Gwyddorau Biolegol, Amgylcheddol a Gwledig / Biological, Environmental & Rural Sciences by Author "Perally, Samirah"

Now showing items 1-7 of 7

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

Fitzpatrick, Jennifer M.; Peak, Emily; Perally, Samirah; Chalmers, Iain W.; Barrett, John; Yoshino, Timothy P.; Ivens, Alasdair C.; Hoffmann, Karl F. (2009-11-03)

Background: Novel methods to identify anthelmintic drug and vaccine targets are urgently needed, especially for thoseparasite species currently being controlled by singular, often limited strategies. A clearer understanding ...
Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum

Liu, S.; Zhan, Bin; Williamson, A.; Perally, Samirah; Fujiwara, R.; Feng, J. J.; Brophy, Peter M.; Liu, Y. Y.; Xiao, S. H.; Xue, J. (2005-10)

We report the cloning and expression of Ac-GST-1, a novel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in parasite blood feeding and as a vaccine target. The predicted Ac-GST-1 ...
Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases

Perally, Samirah; LaCourse, E. James; Campbell, Alison M.; Brophy, Peter M. (2008-08-23)

In contrast to their mammalian hosts, parasitic nematodes are heme auxotrophs and require pathways for the uptake and transport of exogenous heme for incorporation into hemoproteins. Phase II detoxification Nu-class ...
Molecular Cloning, Biochemical Characterization, and Partial Protective Immunity of the Heme-Binding Glutathione S-Transferases from the Human Hookworm Necator americanus

Zhan, Bin; Perally, Samirah; Brophy, Peter M.; Xue, Jian; Goud, Gaddam; Liu, Sen; Deumic, Vehid; de Oliveira, Luciana; Bethony, Jeffrey; Bottazzi, Maria Elena; Jiang, Desheng; Gillespie, Portia; Xiao, Shu-hua; Gupta, Richi; Loukas, Alex; Ranjit, Najju; Lustigman, Sara; Hotez, Peter (2010-04)

Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm ...
Proteomic analyses of Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates a shared detoxification system in longevity assurance

Jones, Laura M.; LaCourse, E. James; Perally, Samirah; Brophy, Peter M.; Staffa, K.; Hamilton, Joanne V. (2010-04-15)

The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses ...
Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica

Morphew, Russell M; Eccleston, Neil; Wilkinson, Toby J; McGarry, John; Perally, Samirah; Prescott, Mark; Ward, Deborah; Williams, Diana; Paterson, Steve; Raman, M; Ravikumar, G; Khalid Saifullah, M; Abbas Abidi, S M; McVeigh, Paul; Maule, Aaron G; Brophy, Peter M; LaCourse, E James (2012)

Fasciolosis is an important foodborne, zoonotic disease of livestock and humans, with global annual health and economic losses estimated at several billion US$. Fasciola hepatica is the major species in temperate regions, ...
A proteomics approach to quantify protein levels following RNA interference: case study with glutathione transferase superfamily from the model metazoan Caenorhabditis elegans

Lacourse, James E.; Perally, Samirah; Hernandez-Viadel, Mariluz; Wright, Hazel A.; Brophy, Peter M. (2008-06-27)

Loss-of-function phenotypic analysis via interference RNA (RNAi) technology is a revolutionary approach to assigning gene function. While transcript-based methodologies commonly validate RNAi gene suppression investigations, ...

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