Show simple item record Jane L. en_US Silvia en_US Manfred en_US Mark en_US Sonia J. en_US John M. en_US Nathaniel D. en_US Cornelia Petronella en_US Chuan en_US Wanchang en_US William M. en_US Michael H. en_US John en_US John W. en_US Murray en_US 2010-08-11T09:01:56Z 2010-08-11T09:01:56Z 2010-08 en_US
dc.identifier en_US
dc.identifier.citation Ward , J L , Forcat , S , Beckmann , M , Bennett , M , Miller , S J , Baker , J M , Hawkins , N D , Vermeer , C P , Lu , C , Lin , W , Truman , W M , Beale , M H , Draper , J , Mansfield , J W & Grant , M 2010 , ' The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. ' Plant Journal , vol 63 , no. 3 , pp. 443-457 . , 10.1111/j.1365-313X.2010.04254.x en_US
dc.identifier.other PURE: 150251 en_US
dc.identifier.other dspace: 2160/5162 en_US
dc.description.abstract The outcome of bacterial infection in plants is determined by the ability of the pathogen to successfully occupy the apoplastic space and deliver a constellation of effectors that collectively suppress basal and effector-triggered immune responses. In this study, we examined the metabolic changes associated with establishment of disease using analytical techniques that interrogated a range of chemistries. We demonstrated clear differences in the metabolome of Arabidopsis thaliana leaves infected with virulent Pseudomonas syringae within 8 h of infection. In addition to confirmation of changes in phenolic and indolic compounds, we identified rapid alterations in the abundance of amino acids and other nitrogenous compounds, specific classes of glucosinolates, disaccharides, and molecules that influence the prevalence of reactive oxygen species. Our data illustrate that, superimposed on defence suppression, pathogens reconfigure host metabolism to provide the sustenance required to support exponentially growing populations of apoplastically localized bacteria. We performed a detailed baseline study reporting the metabolic dynamics associated with bacterial infection. Moreover, we have integrated these data with the results of transcriptome profiling to distinguish metabolomic pathways that are transcriptionally activated from those that are post-transcriptionally regulated. en_US
dc.format.extent 15 en_US
dc.relation.ispartof Plant Journal en_US
dc.subject metabolomic en_US
dc.subject Pseudomonas syringae en_US
dc.subject Arabidopsis thaliana en_US
dc.subject mass spectrometry en_US
dc.subject NMR en_US
dc.title The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US
dc.contributor.pbl Department of Computer Science en_US

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