Show simple item record Ward, Jane L. Forcat, Silvia Beckmann, Manfred Bennett, Mark Miller, Sonia J. Baker, John M. Hawkins, Nathaniel D. Vermeer, Cornelia Petronella Lu, Chuan Lin, Wanchang Truman, William M. Beale, Michael H. Draper, John Mansfield, John W. Grant, Murray 2010-08-11T09:01:56Z 2010-08-11T09:01:56Z 2010-08
dc.identifier.citation Ward , J L , Forcat , S , Beckmann , M , Bennett , M , Miller , S J , Baker , J M , Hawkins , N D , Vermeer , C P , Lu , C , Lin , W , Truman , W M , Beale , M H , Draper , J , Mansfield , J W & Grant , M 2010 , ' The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. ' Plant Journal , vol 63 , no. 3 , pp. 443-457 . DOI: 10.1111/j.1365-313X.2010.04254.x en
dc.identifier.issn 0960-7412
dc.identifier.other PURE: 150251
dc.identifier.other PURE UUID: a7eaaef4-462f-4441-b36a-b7978ceae21e
dc.identifier.other dspace: 2160/5162
dc.identifier.other DSpace_20121128.csv: row: 3624
dc.identifier.other IBERS: 0000018767
dc.identifier.other Ibers_20121112_1204.csv: row: 1008
dc.identifier.other RAD: 10502
dc.identifier.other RAD_Outputs_All_ID_Import_20121105.csv: row: 3732
dc.identifier.other Scopus: 77954898293
dc.identifier.other PubMed: 20497374
dc.description Ward, J. L., Forcat, S., Beckmann, M., Bennett, M., Miller, S. J., Baker, J. M., Hawkins, N. D., Vermeer, C. P., Lu, C., Lin, W., Truman, W. M., Beale, M. H., Draper, J., Mansfield, J. W., & Grant, M. (2010). The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato.Plant Journal, 63 (3), 443-457 Sponsorship: BBSRC IMPF: 06.94 en
dc.description.abstract The outcome of bacterial infection in plants is determined by the ability of the pathogen to successfully occupy the apoplastic space and deliver a constellation of effectors that collectively suppress basal and effector-triggered immune responses. In this study, we examined the metabolic changes associated with establishment of disease using analytical techniques that interrogated a range of chemistries. We demonstrated clear differences in the metabolome of Arabidopsis thaliana leaves infected with virulent Pseudomonas syringae within 8 h of infection. In addition to confirmation of changes in phenolic and indolic compounds, we identified rapid alterations in the abundance of amino acids and other nitrogenous compounds, specific classes of glucosinolates, disaccharides, and molecules that influence the prevalence of reactive oxygen species. Our data illustrate that, superimposed on defence suppression, pathogens reconfigure host metabolism to provide the sustenance required to support exponentially growing populations of apoplastically localized bacteria. We performed a detailed baseline study reporting the metabolic dynamics associated with bacterial infection. Moreover, we have integrated these data with the results of transcriptome profiling to distinguish metabolomic pathways that are transcriptionally activated from those that are post-transcriptionally regulated. en
dc.format.extent 15 en
dc.language.iso eng
dc.relation.ispartof Plant Journal en
dc.rights en
dc.subject metabolomic en
dc.subject Pseudomonas syringae en
dc.subject Arabidopsis thaliana en
dc.subject mass spectrometry en
dc.subject NMR en
dc.title The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.contributor.institution Department of Computer Science en
dc.description.status Peer reviewed en

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair

Advanced Search