The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato.

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dc.contributor.author Ward, Jane L.
dc.contributor.author Forcat, Silvia
dc.contributor.author Beckmann, Manfred
dc.contributor.author Bennett, Mark
dc.contributor.author Miller, Sonia J.
dc.contributor.author Baker, John M.
dc.contributor.author Hawkins, Nathaniel D.
dc.contributor.author Vermeer, Cornelia Petronella
dc.contributor.author Lu, Chuan
dc.contributor.author Lin, Wanchang
dc.contributor.author Truman, William M.
dc.contributor.author Beale, Michael H.
dc.contributor.author Draper, John
dc.contributor.author Mansfield, John W.
dc.contributor.author Grant, Murray
dc.date.accessioned 2010-08-11T09:01:56Z
dc.date.available 2010-08-11T09:01:56Z
dc.date.issued 2010-08
dc.identifier.citation Ward , J L , Forcat , S , Beckmann , M , Bennett , M , Miller , S J , Baker , J M , Hawkins , N D , Vermeer , C P , Lu , C , Lin , W , Truman , W M , Beale , M H , Draper , J , Mansfield , J W & Grant , M 2010 , ' The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. ' Plant Journal , vol 63 , no. 3 , pp. 443-457 . en
dc.identifier.issn 0960-7412
dc.identifier.other PURE: 150251
dc.identifier.other dspace: 2160/5162
dc.identifier.uri http://hdl.handle.net/2160/5162
dc.description Ward, J. L., Forcat, S., Beckmann, M., Bennett, M., Miller, S. J., Baker, J. M., Hawkins, N. D., Vermeer, C. P., Lu, C., Lin, W., Truman, W. M., Beale, M. H., Draper, J., Mansfield, J. W., & Grant, M. (2010). The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato.Plant Journal, 63 (3), 443-457 Sponsorship: BBSRC IMPF: 06.94 en
dc.description.abstract The outcome of bacterial infection in plants is determined by the ability of the pathogen to successfully occupy the apoplastic space and deliver a constellation of effectors that collectively suppress basal and effector-triggered immune responses. In this study, we examined the metabolic changes associated with establishment of disease using analytical techniques that interrogated a range of chemistries. We demonstrated clear differences in the metabolome of Arabidopsis thaliana leaves infected with virulent Pseudomonas syringae within 8 h of infection. In addition to confirmation of changes in phenolic and indolic compounds, we identified rapid alterations in the abundance of amino acids and other nitrogenous compounds, specific classes of glucosinolates, disaccharides, and molecules that influence the prevalence of reactive oxygen species. Our data illustrate that, superimposed on defence suppression, pathogens reconfigure host metabolism to provide the sustenance required to support exponentially growing populations of apoplastically localized bacteria. We performed a detailed baseline study reporting the metabolic dynamics associated with bacterial infection. Moreover, we have integrated these data with the results of transcriptome profiling to distinguish metabolomic pathways that are transcriptionally activated from those that are post-transcriptionally regulated. en
dc.format.extent 15 en
dc.language.iso eng
dc.relation.ispartof Plant Journal en
dc.subject metabolomic en
dc.subject Pseudomonas syringae en
dc.subject Arabidopsis thaliana en
dc.subject mass spectrometry en
dc.subject NMR en
dc.title The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-313X.2010.04254.x
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.contributor.institution Department of Computer Science en
dc.description.status Peer reviewed en


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