The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure

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dc.contributor.author Udey, Mark C.
dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Kamhawi, Shaden
dc.contributor.author Mendez, Susana
dc.contributor.author Belkaid, Yasmine
dc.date.accessioned 2010-09-30T12:38:30Z
dc.date.available 2010-09-30T12:38:30Z
dc.date.issued 2010-09-30
dc.identifier.citation Udey , M C , Hoffmann , K F , Kamhawi , S , Mendez , S & Belkaid , Y 2010 , ' The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure ' Belkaid . en
dc.identifier.other PURE: 160701
dc.identifier.other dspace: 2160/5734
dc.identifier.uri http://hdl.handle.net/2160/5734
dc.description Belkaid, Y., Hoffmann, K. F., Mendez, S., Kamhawi, S., Udey, M. C. (2001). The role of Interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of Anti¿IL-10 receptor antibody for sterile cure. Journal of Experimental Medicine, 194(10), 1497¿1506. en
dc.description.abstract Some pathogens (e.g., Mycobacterium tuberculosis, Toxoplasma gondii, Leishmania spp.) have been shown to persist in their host after clinical cure, establishing the risk of disease reactivation. We analyzed the conditions necessary for the long term maintenance of Leishmania major in genetically resistant C57BL/6 mice after spontaneous healing of their dermal lesions. Interleukin (IL)-10 was found to play an essential role in parasite persistence as sterile cure was achieved in IL-10¿deficient and IL-4/IL-10 double-deficient mice. The requirement for IL-10 in establishing latency associated with natural infection was confirmed in IL-10¿deficient mice challenged by bite of infected sand flies. The host-parasite equilibrium was maintained by CD4 and CD8 T cells which were each able to release IL-10 or interferon (IFN)- , and were found to accumulate in chronic sites of infection, including the skin and draining lymph node. A high frequency of the dermal CD4 T cells released both IL-10 and IFN- . Wild-type mice treated transiently during the chronic phase with anti¿IL-10 receptor antibodies achieved sterile cure, suggesting a novel therapeutic approach to eliminate latency, infection reservoirs, and the risk of reactivation disease. en
dc.language.iso eng
dc.relation.ispartof Belkaid en
dc.title The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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