Experimental Models for the Analysis of IL-10 Function


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dc.contributor.author Wynn, Thomas A.
dc.contributor.author Aliberti, Julio
dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Jankovic, Dragana
dc.contributor.author Feng, Carl G.
dc.contributor.author Kullberg, Marika C.
dc.contributor.author Sher, Alan
dc.contributor.editor Francesco, M. Marincola
dc.date.accessioned 2010-10-07T15:08:17Z
dc.date.available 2010-10-07T15:08:17Z
dc.date.issued 2010-10-07
dc.identifier.citation Wynn , T A , Aliberti , J , Hoffmann , K F , Jankovic , D , Feng , C G , Kullberg , M C & Sher , A 2010 , ' Experimental Models for the Analysis of IL-10 Function ' . M M Francesco (ed.) , in : Interleukin-10 . Landes Bioscience . en
dc.identifier.other PURE: 160903
dc.identifier.other dspace: 2160/5762
dc.identifier.uri http://hdl.handle.net/2160/5762
dc.description Feng, C. G., Aliberti, J., Hoffmann, K. F., Jankovic, D., Kullberg, M. C., Sher, A., Wynn, T. A., Experimental Models for the Analysis of IL-10 Function, In: Interleukin-10, Francesco, M. Marincola (ed), Landes Bioscience, Austen, TX., USA, 2004 en
dc.description.abstract his review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies. The various mechanisms that control the production and activity of IL-10 are also discussed. Studies performed over the past few years illustrate a complex and pleiotropic nature for IL-10 in host immunity. The fact that nearly every cell in the body can respond to IL-10 and multiple cells produce the cytokine likely explains this multifaceted activity. Studies conducted in experimental infectious and inflammatory diseases models have been particularly useful in defining the various regulatory activities of IL-10. Although these studies have identified many common themes for IL-10 in host immunity, they also nicely illustrate how IL-10 fine-tunes the response to individual pathogens and prevents inflammation. en
dc.language.iso eng
dc.publisher Landes Bioscience
dc.relation.ispartof Interleukin-10 en
dc.title Experimental Models for the Analysis of IL-10 Function en
dc.type Text en
dc.type.publicationtype Book chapter en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en

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