Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs

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dc.contributor.author Doenhoff, Michael J.
dc.contributor.author Schramm, Gabriele
dc.contributor.author Wuhrer, Manfred
dc.contributor.author Dunne, David W.
dc.contributor.author Haas, Helmut
dc.contributor.author Grevelding, Christoph G.
dc.contributor.author Fitzsimmons, Colin M.
dc.contributor.author Jones, Frances M.
dc.contributor.author Hokke, Cornelis H.
dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Chalmers, Iain W.
dc.date.accessioned 2010-10-11T15:39:19Z
dc.date.available 2010-10-11T15:39:19Z
dc.date.issued 2010-10-11
dc.identifier.citation Doenhoff , M J , Schramm , G , Wuhrer , M , Dunne , D W , Haas , H , Grevelding , C G , Fitzsimmons , C M , Jones , F M , Hokke , C H , Hoffmann , K F & Chalmers , I W 2010 , ' Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs ' Molecular & Biochemical Parasitology , pp. 123-7 . en
dc.identifier.other PURE: 161085
dc.identifier.other dspace: 2160/5777
dc.identifier.uri http://hdl.handle.net/2160/5777
dc.description Fitzsimmons, C. M., Schramm, G., Jones, F. M., Chalmers, I. W., Hoffmann, K. F., Grevelding, C. G., Wuhrer, M., Hokke, C. H., Haas, H., Doenhoff, M. J., Dunne, D. W. (2005). Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs. Molecular & Biochemical Parasitology, 144(1), pp. 123-7. en
dc.description.abstract During chronic Schistosoma mansoni (S. mansoni) infection parasite eggs lodge in the microvasculature of the host¿s liver provoking inflammation that leads to formation of granuloma and fibrosis around trapped eggs. Murine studies have suggested that this is a protective response in that parenchymal cells do not usually suffer direct damage. In mice immunosuppressed by T-cell deprivation or hydrocortisone treatment however, S. mansoni infection is associated with extensive parenchymal damage, thought to be caused by cytotoxic egg products spreading through the tissue. Affected animals suffer focal and disseminated hepatocyte lesions in which individual cells display microvesicular steatosis (numerous cytoplasmic lipid vesicles) and nuclear degeneration. Coincident with the histological evidence of hepatocyte injury there is an increase in liver transaminases in the plasma and immunosuppressed mice suffer significant mortality once S. mansoni egg deposition in the liver begins. en
dc.format.extent 5 en
dc.language.iso eng
dc.relation.ispartof Molecular & Biochemical Parasitology en
dc.title Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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