Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E.

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dc.contributor.author Dunne, David W.
dc.contributor.author Vennervald, Birgitte J.
dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Kariuki, Henry C.
dc.contributor.author Mwatha, Joseph K.
dc.contributor.author Reimert, Claus M.
dc.contributor.author Fitzsimmons, Colin M.
dc.contributor.author Ouma, John H.
dc.contributor.author Kabatereine, Narcis B.
dc.contributor.author Kazibwe, Francis
dc.contributor.author Jones, Frances M.
dc.contributor.author Joseph, Sarah
dc.contributor.author Tukahebwa, Edridah M.
dc.contributor.author Kimani, Gachuhi
dc.date.accessioned 2010-10-14T10:55:41Z
dc.date.available 2010-10-14T10:55:41Z
dc.date.issued 2010-10-14
dc.identifier.citation Dunne , D W , Vennervald , B J , Hoffmann , K F , Kariuki , H C , Mwatha , J K , Reimert , C M , Fitzsimmons , C M , Ouma , J H , Kabatereine , N B , Kazibwe , F , Jones , F M , Joseph , S , Tukahebwa , E M & Kimani , G 2010 , ' Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. ' Infection and Immunity . en
dc.identifier.other PURE: 161258
dc.identifier.other dspace: 2160/5807
dc.identifier.uri http://hdl.handle.net/2160/5807
dc.description Fitzsimmons, C. M., Joseph, S., Jones, F. M., Reimert, C. M., Hoffmann, K. F., Kazibwe, F., Kimani, G., Mwatha, J. K., Ouma, J. H., Tukahebwa, E. M., Kariuki, H. C., Vennervald, B. J., Kabatereine, N. B., Dunne, D. W. (2004). Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. Infection and Immunity, 72 (7), 4023¿4030 *Corresponding author en
dc.description.abstract Chemotherapy for blood-dwelling schistosomes kills the worms and exposes parasite antigen to the circulation. In many people from areas of endemicity, this treatment increases parasite-specific immunoglobulin E (IgE) and other Th2 responses in the months following therapy, responses that have been associated with subsequent resistance to reinfection. Here we investigate much earlier changes in immune reactions after praziquantel therapy in Schistosoma mansoni-infected fishermen working in an area of high transmission in Uganda. The subjects gave blood before treatment and at 1 and 21 days posttreatment. Blood cultures were incubated with schistosome soluble worm antigen (SWA) or soluble egg antigen (SEA). Interleukin-4 (IL-4), IL-5, IL-10, IL-13, gamma interferon, and transforming growth factor levels were measured in the cultures and in plasma. A marked transient increase in plasma IL-5 levels was observed in 75% of the subjects (n 48) by 1 day posttreatment. This response was dependent on pretreatment intensity of infection and was accompanied by a transient decrease in eosinophil numbers. One day posttreatment, blood cultures from the 16 subjects with the greatest increase in plasma IL-5 level (>100 pg/ml) displayed reduced IL-5, IL-13, and IL-10 responses to SWA, and in contrast to the rest of the cohort, these high-IL-5 subjects displayed reduced levels of SWA-specific IgE in plasma 21 days posttreatment. Twenty months after treatment, the intensity of reinfection was positively correlated with the increase in plasma IL-5 level seen 1 day posttreatment. These studies describe the heterogeneity in early immune reactions to treatment, identifying subgroups who have different patterns of reaction and who may have different capacities to mount the responses that have been associated with resistance to reinfection. en
dc.language.iso eng
dc.relation.ispartof Infection and Immunity en
dc.title Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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