Show simple item record

dc.contributor.author Cheever, Allen W.
dc.contributor.author Davis, Eric M.
dc.contributor.author Morse III, Herbert C.
dc.contributor.author Hesse, Matthias
dc.contributor.author McCarty, Thomas C.
dc.contributor.author Meltzer, Paul S.
dc.contributor.author Segal, David H.
dc.contributor.author Chiaramonte, Monica
dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Wynn, Thomas A.
dc.date.accessioned 2010-10-22T11:12:20Z
dc.date.available 2010-10-22T11:12:20Z
dc.date.issued 2010-10-22
dc.identifier.citation Cheever , A W , Davis , E M , Morse III , H C , Hesse , M , McCarty , T C , Meltzer , P S , Segal , D H , Chiaramonte , M , Hoffmann , K F & Wynn , T A 2010 , ' Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions ' The FASEB Journal , pp. 01-0306 . en
dc.identifier.other PURE: 161566
dc.identifier.other dspace: 2160/5835
dc.identifier.uri http://hdl.handle.net/2160/5835
dc.description Hoffmann, K. F., McCarty, T. C., Segal, D. H., Chiaramonte, M., Hesse, M., Davis, E. M., Cheever, A. W., Meltzer, P. S., Morse III, H. C., Wynn, T. A. (2001). Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions. The FASEB Journal, express article 10.1096/fj.01-0306fje. *Corresponding author en
dc.description.abstract Development of polarized immune responses controls resistance and susceptibility to many microorganisms. However, studies of several infectious, allergic, and autoimmune diseases have shown that chronic type-1 and type-2 cytokine responses can also cause significant morbidity and mortality if left unchecked. We used mouse cDNA microarrays to molecularly phenotype the gene expression patterns that characterize two disparate but equally lethal forms of liver pathology that develop in Schistosoma mansoni infected mice polarized for type-1 and type-2 cytokine responses. Hierarchical clustering analysis identified at least three groups of genes associated with a polarized type-2 response and two linked with an extreme type-1 cytokine phenotype. Predictions about liver fibrosis, apoptosis, and granulocyte recruitment and activation generated by the microarray studies were confirmed later by traditional biological assays. The data show that cDNA microarrays are useful not only for determining coordinated gene expression profiles but are also highly effective for molecularly ¿fingerprinting¿ diseased tissues. Moreover, they illustrate the potential of genome-wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious disease pathogenesis. en
dc.format.extent 306 en
dc.language.iso eng
dc.relation.ispartof The FASEB Journal en
dc.title Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair


Advanced Search

Browse

Statistics