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dc.contributor.author Marchbank, T.
dc.contributor.author Patterson, M.
dc.contributor.author Playford, J. R.
dc.contributor.author Oakes, J. R.
dc.contributor.author Ghatei, M.
dc.contributor.author Davison, Glen
dc.contributor.author Rolfs, J.
dc.date.accessioned 2010-11-16T15:40:56Z
dc.date.available 2010-11-16T15:40:56Z
dc.date.issued 2010-04
dc.identifier.citation Marchbank , T , Patterson , M , Playford , J R , Oakes , J R , Ghatei , M , Davison , G & Rolfs , J 2010 , ' OC-083 Clinical trial: influence of bovine colostrum on intestinal permeability in healthy athletes after heavy exercise ' pp. 34- . , 10.1136/gut.2009.208991e en
dc.identifier.other PURE: 153170
dc.identifier.other dspace: 2160/5900
dc.identifier.uri http://hdl.handle.net/2160/5900
dc.description Marchbank, T., Davison, G., Oakes, J.R., Ghatei, M., Patterson, M., Rolfs, J., Playford, R.J. (2010). OC-083 Clinical trial: influence of bovine colostrum on intestinal permeability in healthy athletes after heavy exercise. Gut, 59 (Suppl. 1, A34-A35. British Society of Gastroenterology Annual General Meeting 2010, Meeting abstracts. en
dc.description.abstract Heavy exercise results in gut symptoms and in extreme cases 'heat stroke' due, in part, to increased intestinal permeability of luminal toxins. We examined if bovine colostrum a rich source of growth factors and immune modulators could prevent these permeability changes. Methods: Twelve healthy volunteers completed a double-blind, placebo-controlled, crossover protocol (14 days colostrum or placebo) prior to standardised exercise. Gut permeability utilised 5 h urinary lactulose: rhamnose ratios. In vitro studies (T84 cells) examined effects of colostrum on temperature-induced apoptosis (active caspase-3) and epithelial resistance. Results: For both arms of study, exercise increased the blood lactate, heart rate, core temperature (mean 2°C rise) and plasma VIP by similar amounts. However, GLP-1 plasma levels results were discordant; rising by 88.7 pmol/l in placebo arm but falling by 4.2 pmol/l in colostrum arm (p=0.026). Intestinal permeability in placebo arm increased 2.5-fold following exercise (0.38±0.012 baseline value, to 0.92±0.014, p en
dc.language.iso eng
dc.relation.ispartof en
dc.title OC-083 Clinical trial: influence of bovine colostrum on intestinal permeability in healthy athletes after heavy exercise en
dc.type Text en
dc.type.publicationtype Conference contribution en
dc.identifier.doi http://dx.doi.org/10.1136/gut.2009.208991e
dc.contributor.institution Department of Sport & Exercise Science en
dc.description.status Non peer reviewed en


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