Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni

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dc.contributor.author Hoffmann, Karl F.
dc.contributor.author Wynn, Thomas A.
dc.contributor.author Cheever, Allen W.
dc.contributor.author James, Stephanie L.
dc.date.accessioned 2011-01-14T12:17:15Z
dc.date.available 2011-01-14T12:17:15Z
dc.date.issued 2011-01-14
dc.identifier.citation Hoffmann , K F , Wynn , T A , Cheever , A W & James , S L 2011 , ' Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni ' The Journal of Immunology , pp. 927 . en
dc.identifier.other PURE: 166343
dc.identifier.other dspace: 2160/6093
dc.identifier.uri http://hdl.handle.net/2160/6093
dc.description Hoffmann, K. F., james, S. L., Cheever, A. W., Wynn, T. A. (1999) Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni. The Journal of Immunology, 163 ', pp. 927¿938 en
dc.description.abstract A fundamental obstacle to vaccine development in schistosomiasis mansoni is a lack of understanding of what type of an immune response should be invoked. We have addressed this central issue by using the radiation-attenuated cercariae vaccine in mice genetically engineered to exhibit highly polarized type 1 (IL-10/IL-4-deficient) or type 2 (IL-10/IL-12-deficient) cytokine and Ab phenotypes. Our data show that while significant differences in immunity exist after a single vaccination with irradiated cercariae in double cytokine-deficient vs wild-type mice, these differences disappear after two vaccinations. The most important finding of these studies, however, was revealed in vaccinated IL-10-deficient mice. These mice developed a mixed and elevated type 1- and type 2-associated immune response and developed anti-schistosome immunity at levels equal to or better than those in wild-type mice. This immunity in IL-10-deficient mice correlated with higher parasite-specific Ab titers, greater proliferative capacity of lymphocytes, increased frequency of IFN-g- and IL-4-secreting cells, elevated perivascular/peribronchial inflammatory responses in the lung, and greater in vitro schistosomulacidal capacity of parasite Ag-elicited cells. These results suggest that optimal vaccine-induced immunity against schistosomes is linked not to the development of a highly polarized response, but, rather, to the induction of both type 1- and type 2-associated immune responses. en
dc.format.extent 927 en
dc.language.iso eng
dc.relation.ispartof The Journal of Immunology en
dc.title Studies with Double Cytokine-Deficient Mice Reveal That Highly Polarized Th1- and Th2-Type Cytokine and Antibody Responses Contribute Equally to Vaccine-Induced Immunity to Schistosoma mansoni en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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