Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover

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dc.contributor.author Hondo, Tetsuya
dc.contributor.author Takahashi, Yu
dc.contributor.author Kanaya, T.
dc.contributor.author Sato, Kan
dc.contributor.author Ogasawara, Hideki
dc.contributor.author Miyake, Masato
dc.contributor.author Saito, Kazuki
dc.contributor.author Takakura, Ikuro
dc.contributor.author al, et
dc.contributor.author Akasaka, Daisuke
dc.contributor.author Watanabe, Hitoshi
dc.date.accessioned 2011-06-03T09:01:18Z
dc.date.available 2011-06-03T09:01:18Z
dc.date.issued 2011-06-03
dc.identifier.citation Hondo , T , Takahashi , Y , Kanaya , T , Sato , K , Ogasawara , H , Miyake , M , Saito , K , Takakura , I , al , Akasaka , D & Watanabe , H 2011 , ' Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover ' Unknown Journal , pp. 4776-4786 . en
dc.identifier.other PURE: 172518
dc.identifier.other dspace: 2160/6899
dc.identifier.uri http://hdl.handle.net/2160/6899
dc.description Watanabe, H., Akasaka, D., Ogasawara, H., Sato, K., Miyake, M., Saito, K., Takahashi, Y., Kanaya, T., Takakura, I., Hondo, T., Chao, G., Rose, M. T., Ohwada, S., Watanabe, K., Yamaguchi, T., Aso, H. (2010). Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover.   Endocrinology, 151, (10), 4776-4786. en
dc.description.abstract Serotonin is synthesized by two distinct tryptophan hydroxylases, one in the brain and one in the periphery. The latter is known to be unable to cross the blood-brain barrier. These two serotonin systems have apparently independent functions, although the functions of peripheral serotonin have yet to be fully elucidated. In this study, we have investigated the physiological effect of peripheral serotonin on the concentrations of metabolites in the circulation and in the liver. After fasting, mice were ip injected with 1 mg serotonin. The plasma glucose concentration was significantly elevated between 60 and 270 min after the injection. In contrast, plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations were decreased. The hepatic glycogen synthesis and concentrations were significantly higher at 240 min. At the same time, the hepatic triglyceride content was significantly lower than the basal levels noted before the serotonin injection, whereas the hepatic cholesterol content was significantly higher by 60 min after the injection. Furthermore, serotonin stimulated the contraction of the gallbladder and the excretion of bile. After the serotonin injection, there was a significant induction of apical sodium-dependent bile acid transporter expression, resulting in a decrease in the concentration of bile acids in the feces. Additionally, data are presented to show that the functions of serotonin are mediated through diverse serotonin receptor subtypes. These data indicate that peripheral serotonin accelerates the metabolism of lipid by increasing the concentration of bile acids in circulation. en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Unknown Journal en
dc.title Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Aberystwyth University en
dc.description.status Peer reviewed en


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