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dc.contributor.author Alice R. en_US
dc.contributor.author David E. en_US
dc.date.accessioned 2011-06-03T10:11:37Z
dc.date.available 2011-06-03T10:11:37Z
dc.date.issued 2010-11-01 en_US
dc.identifier http://dx.doi.org/10.1111/j.1574-6968.2010.02092.x en_US
dc.identifier.citation Evans , A R & Whitworth , D E 2010 , ' Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes ' FEMS Microbiology Letters , vol 312 , no. 1 , pp. 40-45 . , 10.1111/j.1574-6968.2010.02092.x en_US
dc.identifier.other PURE: 163486 en_US
dc.identifier.other dspace: 2160/6905 en_US
dc.identifier.uri http://hdl.handle.net/2160/6905
dc.description.abstract Myxobacterial development requires the coordinated action of both intracellular and intercellular signalling pathways. A dataset of myxobacterial developmental gene properties suggests that genes encoding components of intracellular pathways tend to be less conserved, yield less severe phenotypes upon deletion and lie closer to the chromosomal origin than intercellular signalling genes. It would seem that there is a stronger negative selection affecting the mutation of intercellular signalling pathway genes than intracellular genes. Presumably, this is because the loss of social behaviour (and consequently sporulation) upon mutation of an intercellular gene is profoundly detrimental to the perpetuation of the organism. Conversely, mutation of an intracellular gene would typically result in a socially capable mutant. The correlations presented here between the severity of phenotype, genomic location and the degree of sequence conservation should aid rational exploration of the genomics of social development in the myxobacteria. en_US
dc.format.extent 6 en_US
dc.relation.ispartof FEMS Microbiology Letters en_US
dc.subject myxobacteria en_US
dc.subject multicellelarity en_US
dc.subject fruiting body formation en_US
dc.title Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes en_US
dc.contributor.pbl Institute of Biological, Environmental and Rural Sciences en_US


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