Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes

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dc.contributor.author Whitworth, David E.
dc.contributor.author Evans, Alice R.
dc.date.accessioned 2011-06-03T10:11:37Z
dc.date.available 2011-06-03T10:11:37Z
dc.date.issued 2010-11-01
dc.identifier.citation Whitworth , D E & Evans , A R 2010 , ' Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes ' FEMS Microbiology Letters , vol 312 , no. 1 , pp. 40-45 . , 10.1111/j.1574-6968.2010.02092.x en
dc.identifier.issn 0378-1097
dc.identifier.other PURE: 163486
dc.identifier.other dspace: 2160/6905
dc.identifier.uri http://hdl.handle.net/2160/6905
dc.description Evans, A. R., Whitworth, D. E. (2010). Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes.   FEMS Microbiology Letters, 312, (1), 40-45. IMPF: 02.04 Sponsorship: EU; Welsh Assembly Government en
dc.description.abstract Myxobacterial development requires the coordinated action of both intracellular and intercellular signalling pathways. A dataset of myxobacterial developmental gene properties suggests that genes encoding components of intracellular pathways tend to be less conserved, yield less severe phenotypes upon deletion and lie closer to the chromosomal origin than intercellular signalling genes. It would seem that there is a stronger negative selection affecting the mutation of intercellular signalling pathway genes than intracellular genes. Presumably, this is because the loss of social behaviour (and consequently sporulation) upon mutation of an intercellular gene is profoundly detrimental to the perpetuation of the organism. Conversely, mutation of an intracellular gene would typically result in a socially capable mutant. The correlations presented here between the severity of phenotype, genomic location and the degree of sequence conservation should aid rational exploration of the genomics of social development in the myxobacteria. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof FEMS Microbiology Letters en
dc.subject myxobacteria en
dc.subject multicellelarity en
dc.subject fruiting body formation en
dc.title Correlations between the role, sequence conservation, genomic location and severity of phenotype in myxobacterial developmental genes en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1111/j.1574-6968.2010.02092.x
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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