Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium

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dc.contributor.author Young, M.
dc.contributor.author Artsatbanov, Vladislav
dc.contributor.author Beller, Harry R.
dc.contributor.author Chandra, Govind
dc.contributor.author Chater, Keith F.
dc.contributor.author Dover, Lynn G.
dc.contributor.author Goh, Ee-Been
dc.contributor.author Kahan, Tamar
dc.contributor.author Kaprelyants, Arseny S.
dc.contributor.author Kyrpides, Nikos
dc.contributor.author Lapidus, Alla
dc.contributor.author Lowry, Stephen R.
dc.contributor.author Lykidis, Athanasios
dc.contributor.author Mahillon, Jacques
dc.contributor.author Markowitz, Victor
dc.contributor.author Mavromatis, Konstantinos
dc.contributor.author Mukamolova, Galina V.
dc.contributor.author Oren, Aharon
dc.contributor.author Rokem, J. Stefan
dc.contributor.author Smith, Margaret C. M.
dc.contributor.author Young, D. I.
dc.contributor.author Greenblatt, Charles L.
dc.date.accessioned 2011-06-07T10:55:22Z
dc.date.available 2011-06-07T10:55:22Z
dc.date.issued 2010-02-01
dc.identifier.citation Young , M , Artsatbanov , V , Beller , H R , Chandra , G , Chater , K F , Dover , L G , Goh , E-B , Kahan , T , Kaprelyants , A S , Kyrpides , N , Lapidus , A , Lowry , S R , Lykidis , A , Mahillon , J , Markowitz , V , Mavromatis , K , Mukamolova , G V , Oren , A , Rokem , J S , Smith , M C M , Young , D I & Greenblatt , C L 2010 , ' Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium ' Journal of Bacteriology , vol 192 , no. 3 , pp. 841-860 . , 10.1128/JB.01254-09 en
dc.identifier.issn 0021-9193
dc.identifier.other PURE: 164118
dc.identifier.other dspace: 2160/6998
dc.identifier.uri http://hdl.handle.net/2160/6998
dc.description Young, M., Artsatbanov, V., Beller, H. R., Chandra, G., Chater, K. F., Dover, L. G., Goh, E.-B., Kahan, T., Kaprelyants, A. S., Kyrpides, N., Lapidus, A., Lowry, S. R., Lykidis, A., Mahillon, J., Markowitz, V., Mavromatis, K., Mukamolova, G. V., Oren, A., Rokem, J. S., Smith, M. C. M., Young, D. I., Greenblatt, C. L. (2010). Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium. Journal of Bacteriology, 192(3), 841-860. Online early IMPF: 03.72 Sponsorship: British Council; Israeli Ministry of Science and Technology; Hebrew University en
dc.description.abstract Micrococcus luteus (NCTC2665, 'Fleming strain') has one of the smallest genomes of free-living actinobacteria sequenced to date, comprising a single circular chromosome of 2,501,097 bp (G+C content, 73%) predicted to encode 2,403 proteins. The genome shows extensive synteny with that of the closely related organism, Kocuria rhizophila, from which it was taxonomically separated relatively recently. Despite its small size, the genome harbors 73 insertion sequence (IS) elements, almost all of which are closely related to elements found in other actinobacteria. An IS element is inserted into the rrs gene of one of only two rrn operons found in M. luteus. The genome encodes only four sigma factors and 14 response regulators, a finding indicative of adaptation to a rather strict ecological niche (mammalian skin). The high sensitivity of M. luteus to beta-lactam antibiotics may result from the presence of a reduced set of penicillin-binding proteins and the absence of a wblC gene, which plays an important role in the antibiotic resistance in other actinobacteria. Consistent with the restricted range of compounds it can use as a sole source of carbon for energy and growth, M. luteus has a minimal complement of genes concerned with carbohydrate transport and metabolism and its inability to utilize glucose as a sole carbon source may be due to the apparent absence of a gene encoding glucokinase. Uniquely among characterized bacteria, M. luteus appears to be able to metabolize glycogen only via trehalose and to make trehalose only via glycogen. It has very few genes associated with secondary metabolism. In contrast to most other actinobacteria, M. luteus encodes only one resuscitation-promoting factor (Rpf) required for emergence from dormancy, and its complement of other dormancy-related proteins is also much reduced. M. luteus is capable of long-chain alkene biosynthesis, which is of interest for advanced biofuel production; a three-gene cluster essential for this metabolism has been identified in the genome. en
dc.format.extent 20 en
dc.language.iso eng
dc.relation.ispartof Journal of Bacteriology en
dc.title Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1128/JB.01254-09
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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