Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture.

H...............H

Show simple item record

dc.contributor.author Rose, Michael T.
dc.contributor.author Watts, Emma J.
dc.date.accessioned 2011-06-20T15:51:59Z
dc.date.available 2011-06-20T15:51:59Z
dc.date.issued 2011-06-20
dc.identifier.citation Rose , M T & Watts , E J 2011 , ' Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture. ' Watts . en
dc.identifier.other PURE: 177049
dc.identifier.other dspace: 2160/7087
dc.identifier.uri http://hdl.handle.net/2160/7087
dc.description Watts, E. J., Rose, M. T. (2011). Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture Research in Veterinary Science en
dc.description.abstract Wounds on the limbs of horses are notoriously difficult to heal, with over production of TGF¿1 thought to be responsible for excessive scarring; in contrast, wounds in the oral cavity heal rapidly with minimal scarring. This experiment aimed to determine the effect of TGF¿1 on the production of mRNA and proteins for various extracellular matrix components by two equine fibroblast cell lines isolated from the oral mucosa and distal limb. Fibronectin mRNA was up-regulated by TGF¿1 in the limb but not the oral cells. TGF¿1 increased the ratio of mRNA for collagen types I¿III for the oral cells only. mRNA expression for TGF¿ receptors-I and -II was significantly lower in limb fibroblasts, and treatment of either cell line with TGF¿1 down-regulated mRNA expression for both receptors. These differences may account for the improved healing seen in oral wounds compared to the excessive scarring seen in limb wounds. en
dc.language.iso eng
dc.relation.ispartof Watts en
dc.title Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture. en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair


Advanced Search

Browse

My Account