Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water

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dc.contributor.author Eyto, Elvira de
dc.contributor.author McGinnity, Philip
dc.contributor.author Huisman, Jisca
dc.contributor.author Coughlan, Jamie
dc.contributor.author Olmo, Sofia Consuegra Del
dc.contributor.author Farrell, Killian
dc.contributor.author O'Toole, Ciar
dc.contributor.author Tufto, Jarle
dc.contributor.author Megens, Hendrik-Jan
dc.contributor.author Jordan, William
dc.contributor.author Cross, Tom
dc.contributor.author Stet, Rene J. M.
dc.date.accessioned 2011-12-12T14:55:17Z
dc.date.available 2011-12-12T14:55:17Z
dc.date.issued 2011-10-04
dc.identifier.citation Eyto , E D , McGinnity , P , Huisman , J , Coughlan , J , Olmo , S C D , Farrell , K , O'Toole , C , Tufto , J , Megens , H-J , Jordan , W , Cross , T & Stet , R J M 2011 , ' Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water ' Evolutionary Applications , vol 4 , no. 6 , pp. 749-762 . en
dc.identifier.issn 1752-4571
dc.identifier.other PURE: 174610
dc.identifier.other dspace: 2160/7725
dc.identifier.uri http://hdl.handle.net/2160/7725
dc.description de Eyto, E., McGinnity, P., Huisman, J., Coughlan, J., Consuegra, S., Farrell, K., O'Toole, C., Tuffo, J., Megens, H-J., Jordan, W., Cross, T., Stet, R. J. M. (2011). Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water. Evolutionary Applications, 4, (6), 749-762. otherstatus: Online Early view IMPF: 04.91 en
dc.description.abstract Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life-history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture. en
dc.format.extent 14 en
dc.language.iso eng
dc.relation.ispartof Evolutionary Applications en
dc.subject Atlantic salmon en
dc.subject freshwater life stages en
dc.subject major histocompatibility en
dc.subject natural selection en
dc.subject Salmo salar en
dc.title Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1111/j.1752-4571.2011.00197.x
dc.contributor.institution Institute of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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