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dc.contributor.author Mark en_US
dc.contributor.author Claire en_US
dc.contributor.author Rhys en_US
dc.contributor.author Jonathan H. en_US
dc.date.accessioned 2008-11-05T14:25:55Z
dc.date.available 2008-11-05T14:25:55Z
dc.date.issued 2006-05-01 en_US
dc.identifier http://dx.doi.org/10.1113/expphysiol.2005.032805 en_US
dc.identifier.citation Burnley , M , Roberts , C , Thatcher , R & Doust , J H 2006 , ' Influence of blood donation on O-2 uptake on-kinetics, peak O-2 uptake and time to exhaustion during severe-intensity cycle exercise in humans ' Experimental Physiology , vol 91 , pp. 499-509 . , 10.1113/expphysiol.2005.032805 en_US
dc.identifier.other PURE: 79468 en_US
dc.identifier.other dspace: 2160/778 en_US
dc.identifier.uri http://hdl.handle.net/2160/778
dc.description.abstract We hypothesized that the reduction of O2-carrying capacity caused by the withdrawal of 450 ml blood would result in slower phase II O2 uptake kinetics, a lower and a reduced time to exhaustion during severe-intensity cycle exercise. Eleven healthy subjects (mean ±S.D. age 23 ± 6 years, body mass 77.2 ± 11.0 kg) completed ‘step’ exercise tests from unloaded cycling to a severe-intensity work rate (80% of the difference between the predetermined gas exchange threshold and the ) on two occasions before, and 24 h following, the voluntary donation of 450 ml blood. Oxygen uptake was measured breath-by-breath, and kinetics estimated using non-linear regression techniques. The blood withdrawal resulted in a significant reduction in haemoglobin concentration (pre: 15.4 ± 0.9 versus post: 14.7 ± 1.3 g dl–1; 95% confidence limits (CL): –0.04, –1.38) and haematocrit (pre: 44 ± 2 versus post: 41 ± 3%; 95% CL: –1.3, –5.1). Compared to the control condition, blood withdrawal resulted in significant reductions in (pre: 3.79 ± 0.64 versus post: 3.64 ± 0.61 l min–1; 95% CL: –0.04, – 0.27) and time to exhaustion (pre: 375 ± 129 versus post: 321 ± 99 s; 95% CL: –24, –85). However, the kinetic parameters of the fundamental response, including the phase II time constant (pre: 29 ± 8 versus post: 30 ± 6 s; 95% CL: 5, –3), were not altered by blood withdrawal. The magnitude of the slow component was significantly reduced following blood donation owing to the lower attained. We conclude that a reduction in blood O2-carrying capacity, achieved through the withdrawal of 450 ml blood, results in a significant reduction in and exercise tolerance but has no effect on the fundamental phase of the on-kinetics during severe-intensity exercise. en_US
dc.format.extent 11 en_US
dc.relation.ispartof Experimental Physiology en_US
dc.title Influence of blood donation on O-2 uptake on-kinetics, peak O-2 uptake and time to exhaustion during severe-intensity cycle exercise in humans en_US
dc.contributor.pbl Department of Sport & Exercise Science en_US


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