Show simple item record

dc.contributor.author Davison, Glen
dc.contributor.author Gleeson, Michael
dc.date.accessioned 2008-11-05T14:30:26Z
dc.date.available 2008-11-05T14:30:26Z
dc.date.issued 2006-07
dc.identifier.citation Davison , G & Gleeson , M 2006 , ' The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man ' European Journal of Applied Physiology , vol 97 , no. 4 , pp. 454-461 . , 10.1007/s00421-006-0196-7 en
dc.identifier.issn 1439-6319
dc.identifier.other PURE: 79674
dc.identifier.other dspace: 2160/780
dc.identifier.uri http://hdl.handle.net/2160/780
dc.description Davison G, Gleeson M, 2006. The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man. European Journal of Applied Physiology 97(4): 454-461 RAE2008 en
dc.description.abstract An increased systemic concentration of stress hormones (of the hypothalamic-pituitary adrenal axis) and some cytokines may contribute to the depression of immune cell function typically observed after prolonged exercise. The aim of the present study was to determine the effect of 2 weeks of supplementation with vitamin C (VC) on cortisol, adrenocorticotrophic hormone, interleukin-6, oxidative stress and neutrophil responses to a single bout of endurance exercise. Nine healthy endurance-trained males exercised for 2.5 h at 60% after 2 weeks of placebo (PLA) or VC (1,000 mg day−1) supplementation. All participants completed both trials utilising a randomised crossover design with a minimum 14 day washout period between trials. There was a significant trial × time interaction effect for plasma cortisol concentration (P = 0.039) which tended to be lower in the VC trial but post hoc analysis found no specific between trial differences. There was a significantly lower post-exercise neutrophilia (P <0.014) in the VC trial, compared with the PLA trial. There was no trial × time interaction for measures of neutrophil function (bacteria-stimulated elastase release, fMLP or PMA-stimulated oxidative burst). However, there was a trend for higher fMLP-stimulated neutrophil oxidative burst in the VC compared with PLA trial (trial × time interaction, P = 0.075). These results suggest that supplementation with VC for a period of up to 2 weeks provides little to no protection against the depression of neutrophil function which typically occurs after endurance exercise. en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof European Journal of Applied Physiology en
dc.subject Ascorbate en
dc.subject Neutrophil en
dc.subject Stress hormone en
dc.subject Cytokine en
dc.subject Oxidative burst en
dc.title The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1007/s00421-006-0196-7
dc.contributor.institution Department of Sport & Exercise Science en
dc.description.status Peer reviewed en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Cadair


Advanced Search

Browse

Statistics