Antioxidant supplementation and immunoendocrine responses to prolonged exercise

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dc.contributor.author Gleeson, Michael
dc.contributor.author Davison, Glen
dc.contributor.author Phillips, Shaun
dc.date.accessioned 2008-11-05T14:56:21Z
dc.date.available 2008-11-05T14:56:21Z
dc.date.issued 2007
dc.identifier.citation Gleeson , M , Davison , G & Phillips , S 2007 , ' Antioxidant supplementation and immunoendocrine responses to prolonged exercise ' Medicine and Science in Sports and Exercise , vol 39 , no. 4 , pp. 645-652 . en
dc.identifier.issn 0195-9131
dc.identifier.other PURE: 79712
dc.identifier.other dspace: 2160/788
dc.identifier.uri http://hdl.handle.net/2160/788
dc.description Davison, Glen, et al., 'Antioxidant supplementation and immunoendocrine responses to prolonged exercise', Medicine and Science in Sports and Exercise, (2007) 39(4) pp.645-652 RAE2008 en
dc.description.abstract Purpose: Antioxidant supplementation may modulate systemic cortisol and interleukin-6 (IL-6) responses to prolonged exercise, but it is unclear whether such effects are also associated with a reduction in the magnitude of immunodepression. The purpose of the present study was to examine the effects of daily vitamin C (L-ascorbic acid, 1000 mg·d-1) and vitamin E (RRR-alpha-tocopherol, 400 IU·d-1) supplementation on immunoendocrine responses to prolonged exercise. Methods: Twenty healthy, recreationally active males cycled for 2.5 h at approximately 60% of maximal oxygen uptake after 4 wk of placebo (PLA, N = 10) or antioxidant (AO, N = 10) supplementation. Results: A significant group x time interaction was observed for plasma cortisol concentration (P = 0.008), and the postexercise increase was greater (P <0.05) in the PLA compared with AO group (approximately 170% compared with an approximately 120% increase above baseline). Plasma IL-6 concentration was significantly increased after exercise to a similar extent in both groups. Plasma free F2-isoprostane concentration was significantly increased after exercise and was unaffected by AO supplementation, whereas plasma TBARS was unaffected by exercise in the PLA group but was lower after exercise in the AO group than in the PLA group. Circulating neutrophil count was significantly increased after exercise, and in vitro bacteria-stimulated elastase release per neutrophil was significantly decreased to a similar extent in both groups. Conclusions: These results suggest that 4 wk of AO supplementation may blunt the cortisol response to a single 2.5-h bout of prolonged exercise independently of changes in oxidative stress or plasma IL-6 concentration, but it is not effective at modulating the exercise-induced neutrophilia or depression of neutrophil function. en
dc.format.extent 8 en
dc.language.iso eng
dc.relation.ispartof Medicine and Science in Sports and Exercise en
dc.title Antioxidant supplementation and immunoendocrine responses to prolonged exercise en
dc.type Text en
dc.type.publicationtype Article (Journal) en
dc.identifier.doi http://dx.doi.org/10.1249/mss.0b013e318031303d
dc.contributor.institution Department of Sport & Exercise Science en
dc.description.status Peer reviewed en


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