Show simple item record Hamdi, I. Payne, S. J. Barton, D. E. McMahon, R. Green, M. Shneerson, J. M. Hales, C. N. 2013-11-18T21:10:16Z 2013-11-18T21:10:16Z 1993-04
dc.identifier.citation Hamdi , I , Payne , S J , Barton , D E , McMahon , R , Green , M , Shneerson , J M & Hales , C N 1993 , ' Genotype analysis in cystic fibrosis in relation to the occurrence of diabetes mellitus ' Clinical Genetics , vol 43 , no. 4 , pp. 186-189 . DOI: 10.1111/j.1399-0004.1993.tb04445.x en
dc.identifier.issn 0009-9163
dc.identifier.other PURE: 3537718
dc.identifier.other PURE UUID: ec10e75f-0571-4439-9e08-5589938ac67c
dc.identifier.other PubMed: 7687208
dc.identifier.other Scopus: 0027219560
dc.identifier.other 2160/12653
dc.description.abstract Carbohydrate intolerance and frank diabetes mellitus (DM) are recognised features of cystic fibrosis (CF), but their cause has not been established. Damage to the islet cells due to pancreatic fibrosis is the most common explanation. The relationship between the genotype and the occurrence of diabetes mellitus has been examined in 21 cystic fibrosis patients attending our out-patient chest clinics. DNA samples were tested for the presence of the most common mutation (delta F508) and the results related to the degree of carbohydrate intolerance. We found that in CF patients over 18 years of age diabetes is more frequent among those homozygous for the delta F508 allele than the heterozygotes (P <0.05). Those homozygous for delta F508 were diagnosed as CF at an earlier age than the heterozygotes (P <0.05). Both the mean age and the female/male ratio were similar in the diabetic and non-diabetic groups. The prevalence of the delta F508 allele was similar to that expected in a random sample of East Anglian cystic fibrosis patients. These data suggest that the occurrence of diabetes mellitus in patients with cystic fibrosis is related to the genotype, which could be secondary to the way the genetic factors influence the degree of pancreatic disease and its rate of progression. en
dc.format.extent 4 en
dc.language.iso eng
dc.relation.ispartof Clinical Genetics en
dc.rights en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Cystic Fibrosis en
dc.subject Cystic Fibrosis Transmembrane Conductance Regulator en
dc.subject Diabetes Mellitus en
dc.subject Female en
dc.subject Gene Frequency en
dc.subject Genotype en
dc.subject Glucose Tolerance Test en
dc.subject Humans en
dc.subject Male en
dc.subject Membrane Proteins en
dc.subject Mutation en
dc.title Genotype analysis in cystic fibrosis in relation to the occurrence of diabetes mellitus en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Department of Biological, Environmental and Rural Sciences en
dc.contributor.institution Department of Lifelong Learning en
dc.description.status Peer reviewed en

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