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dc.contributor.author Engle, D. B.
dc.contributor.author Osmani, S. A.
dc.contributor.author Osmani, A. H.
dc.contributor.author Rosborough, S.
dc.contributor.author Xin, X. N.
dc.contributor.author Morris, N. R.
dc.contributor.author Doonan, John Hugh
dc.date.accessioned 2013-11-26T21:07:24Z
dc.date.available 2013-11-26T21:07:24Z
dc.date.issued 1990-09-25
dc.identifier.citation Engle , D B , Osmani , S A , Osmani , A H , Rosborough , S , Xin , X N , Morris , N R & Doonan , J H 1990 , ' A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein ' Journal of Biological Chemistry , vol 265 , no. 27 , pp. 16132-16137 . en
dc.identifier.issn 0021-9258
dc.identifier.other PURE: 844532
dc.identifier.other PURE UUID: 2ab88c97-278a-495e-aff1-de204a46ce87
dc.identifier.other PubMed: 1697851
dc.identifier.other Scopus: 0025103788
dc.identifier.other handle.net: 2160/12820
dc.identifier.uri http://hdl.handle.net/2160/12820
dc.identifier.uri http://www.jbc.org/content/265/27/16132.abstract en
dc.description.abstract The temperature-sensitive cell cycle mutation bimE7 of Aspergillus nidulans causes cells to become blocked in mitosis at a restrictive temperature. Previous work has shown that this mitotic block is induced even when cells are arrested in the S or G2 phase. The mitotic block is also observed in cells carrying a null mutation in bimE, obtained by molecular disruption of the gene (Osmani, S.A., Engle, D.B., Doonan, J.H., and Morris, N.R. (1988) Cell 52, 241-251), indicating that a lack of bimE function is responsible for the phenotype. We have cloned the bimE gene by complementation of the mutant phenotype and have isolated and sequenced its corresponding cDNA. The gene product is encoded by a 6.5-7-kilobase mRNA. The deduced amino acid sequence suggests a protein with three transmembrane domains. The sequence contains numerous potential N-glycosylation sites and several putative cAMP-dependent phosphorylation sites. No homologous protein sequences were found in the common data bases. The bimE gene product is a novel component in the regulation of mitosis. en
dc.format.extent 6 en
dc.language.iso eng
dc.relation.ispartof Journal of Biological Chemistry en
dc.rights en
dc.title A negative regulator of mitosis in Aspergillus is a putative membrane-spanning protein en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.contributor.institution Department of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en


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