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dc.contributor.author Broome, Matthew
dc.contributor.author He, Zhimin
dc.contributor.author Iftikhar, Mashal
dc.contributor.author Eyden, Julie
dc.contributor.author Marwaha, Steven
dc.date.accessioned 2016-11-03T23:04:12Z
dc.date.available 2016-11-03T23:04:12Z
dc.date.issued 2015-04
dc.identifier.citation Broome , M , He , Z , Iftikhar , M , Eyden , J & Marwaha , S 2015 , ' Neurobiological and behavioural studies of affective instability in clinical populations: systematic review. ' Neuroscience and Biobehavioral Reviews , vol 51 , pp. 243-254 . DOI: 10.1016/j.neubiorev.2015.01.021 en
dc.identifier.issn 0149-7634
dc.identifier.other PURE: 9893374
dc.identifier.other PURE UUID: d2ab79d6-483b-438b-9214-410ad278136b
dc.identifier.other Scopus: 84923016497
dc.identifier.other PubMed: 25662294
dc.identifier.other handle.net: 2160/44028
dc.identifier.uri http://hdl.handle.net/2160/44028
dc.description.abstract Objectives To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations. Data sources A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included. Review methods Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised. Results Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder. Conclusions The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development en
dc.format.extent 11 en
dc.language.iso eng
dc.relation.ispartof Neuroscience and Biobehavioral Reviews en
dc.rights en
dc.subject mood en
dc.subject affective en
dc.subject instability en
dc.subject dysregulation en
dc.subject lability en
dc.subject emotion en
dc.subject bipolar en
dc.subject borderline en
dc.subject RDoC en
dc.title Neurobiological and behavioural studies of affective instability in clinical populations: systematic review. en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.identifier.doi https://doi.org/10.1016/j.neubiorev.2015.01.021
dc.contributor.institution Department of Psychology en
dc.description.status Peer reviewed en


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