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dc.contributor.author Franzmeier, Nicolai
dc.contributor.author Göttler, Jens
dc.contributor.author Grimmer, Timo
dc.contributor.author Drzezga, Alexander
dc.contributor.author Araque Caballero, Miguel A.
dc.contributor.author Simon-Vermot, Lee
dc.contributor.author Taylor, Alexander
dc.contributor.author Beurger, Katharina
dc.contributor.author Catak, Cihan
dc.contributor.author Janowitz, Daniel
dc.contributor.author Mueller, Claudia
dc.contributor.author Duering, Marco
dc.contributor.author Sorg, Christian
dc.contributor.author Ewers, Michael
dc.date.accessioned 2018-08-29T18:34:50Z
dc.date.available 2018-08-29T18:34:50Z
dc.date.issued 2017-08-07
dc.identifier.citation Franzmeier , N , Göttler , J , Grimmer , T , Drzezga , A , Araque Caballero , M A , Simon-Vermot , L , Taylor , A , Beurger , K , Catak , C , Janowitz , D , Mueller , C , Duering , M , Sorg , C & Ewers , M 2017 , ' Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment ' Frontiers in Aging Neuroscience , vol 9 , pp. 264 . DOI: 10.3389/fnagi.2017.00264 en
dc.identifier.issn 1663-4365
dc.identifier.other PURE: 27495479
dc.identifier.other PURE UUID: 351c5902-1b4e-465b-95ac-ff36fb9dd26a
dc.identifier.other Scopus: 85027191359
dc.identifier.other PubMed: 28824423
dc.identifier.other PubMedCentral: PMC5545597
dc.identifier.other handle.net: 2160/46923
dc.identifier.uri http://hdl.handle.net/2160/46923
dc.description.abstract Reserve refers to the phenomenon of relatively preserved cognition in disproportion to the extent of neuropathology, e.g., in Alzheimer’s disease. A putative functional neural substrate underlying reserve is global functional connectivity of the left lateral frontal cortex (LFC, Brodmann Area 6/44). Resting-state fMRI-assessed global LFCconnectivity is associated with protective factors (education) and better maintenance of memory in mild cognitive impairment (MCI). Since the LFC is a hub of the frontoparietal control network that regulates the activity of other networks, the question arises whether LFC-connectivity to specific networks rather than the whole-brain may underlie reserve. We assessed resting-state fMRI in 24 MCI and 16 healthy controls (HC) and in an independent validation sample (23 MCI/32 HC). Seed-based LFC-connectivity to seven major resting-state networks (i.e., fronto-parietal, limbic, dorsal-attention, somatomotor, default-mode, ventral-attention, visual) was computed, reserve was quantified as residualized memory performance after accounting for age and hippocampal atrophy. In both samples of MCI, LFC-activity was anti-correlated with the default-mode network (DMN), but positively correlated with the dorsal-attention network (DAN). Greater education predicted stronger LFC-DMN-connectivity (anticorrelation) and LFC-DAN-connectivity. Stronger LFC-DMN and LFC-DAN-connectivity each predicted higher reserve, consistently in both MCI samples. No associations were detected for LFC-connectivity to other networks. These novel results extend our previous findings on global functional connectivity of the LFC, showing that LFCconnectivity specifically to the DAN and DMN, two core memory networks, enhances reserve in the memory domain in MCI. en
dc.language.iso eng
dc.relation.ispartof Frontiers in Aging Neuroscience en
dc.rights en
dc.subject Cognitive reserve en
dc.subject mild cognitive impairment en
dc.subject frontoparietal control network en
dc.subject memory en
dc.subject Functional connectivity en
dc.title Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.description.version publishersversion en
dc.identifier.doi https://doi.org/10.3389/fnagi.2017.00264
dc.contributor.institution Department of Psychology en
dc.description.status Peer reviewed en


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