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dc.contributor.author Nader, Johanna
dc.contributor.author Mathers, Thomas
dc.contributor.author Ward, Ben
dc.contributor.author Pachebat, Justin Alexander
dc.contributor.author Swain, Martin
dc.contributor.author Robinson, Guy
dc.contributor.author Chalmers, Rachel M.
dc.contributor.author Hunter, Paul R.
dc.contributor.author van Oosterhout, Cock
dc.contributor.author Tyler, Kevin
dc.date.accessioned 2020-02-22T23:53:08Z
dc.date.available 2020-02-22T23:53:08Z
dc.date.issued 2019-03-04
dc.identifier.citation Nader , J , Mathers , T , Ward , B , Pachebat , J A , Swain , M , Robinson , G , Chalmers , R M , Hunter , P R , van Oosterhout , C & Tyler , K 2019 , ' The evolutionary genomics of anthroponosis in Cryptosporidium ' Nature Microbiology . https://doi.org/10.1038/s41564-019-0377-x en
dc.identifier.issn 2058-5276
dc.identifier.other PURE: 25836477
dc.identifier.other PURE UUID: 5b5382a1-5849-4cba-a667-57e83a55af2e
dc.identifier.other ORCID: /0000-0003-3369-3205/work/57013099
dc.identifier.other Scopus: 85062467398
dc.identifier.other handle.net: http://hdl.handle.net/2160/5b5382a1-5849-4cba-a667-57e83a55af2e
dc.identifier.uri http://hdl.handle.net/2160/47147
dc.description.abstract Human cryptosporidiosis is a leading protozoan cause of diarrhoeal mortality worldwide, and a preponderance of infections is caused by anthroponotic Cryptosporidium hominis and zoonotic Cryptosporidium parvum. In this study, we analyse 21 whole genome sequences (WGS) to elucidate the evolution and phylogeny of strictly human-infecting strains and generalist zoonotic strains. In addition, we conduct a meta-analysis to establish the distribution of Cryptosporidium species and subtypes globally, and describe the evolutionary changes of this pathogen during its association with its human host. Here, we show that the C. parvum forms two sister groups; an anthroponotic and zoonotic phenotype. We propose to split these into two separate subspecies; C. parvum parvum (Cpp) and C. parvum anthroponosum (Cpa) for the following reasons. Firstly, Cpa possesses a common subset of loci undergoing rapid convergent evolution driven by positive selection. Secondly, a relative excess of frameshift indels in Cpa and other strains with narrow host range is consistent with adaptation to a single species, i.e. the human host. Thirdly, the population genetic structure in Europe differs markedly between Cpp (isolation-by-distance) and Cpa (admixed population structure). Finally, we detect an elevated level of genetic introgression in the Cpa genome around potential virulence factors, and in genes under positive selection. Our analyses show that genetic introgression between subtypes and species plays a prominent role throughout the evolution of Cryptosporidium, and that the four human-infective Cryptosporidium (sub)species included in this study speciated recently, possibly within the past millennium. en
dc.language.iso eng
dc.relation.ispartof Nature Microbiology en
dc.rights en
dc.title The evolutionary genomics of anthroponosis in Cryptosporidium en
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article en
dc.description.version authorsversion en
dc.identifier.doi https://doi.org/10.1038/s41564-019-0377-x
dc.contributor.institution Department of Biological, Environmental and Rural Sciences en
dc.description.status Peer reviewed en
dc.date.embargoedUntil 04-09-20


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